Total Synthesis of Ecteinascidin 743
Journal of the American Chemical Society2002Vol. 124(23), pp. 6552–6554
Citations Over TimeTop 10% of 2002 papers
Abstract
The total synthesis of ecteinascidin 743 (1), an extremely potent antitumor agent, has been accomplished. The synthesis features Ugi's 4CC reaction, intramolecular Heck reaction, phenol-aldehyde cyclization, and acid-induced intramolecular sulfide formation.
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