Asymmetric Synthesis of syn- and anti-1,3-Amino Alcohols
Journal of the American Chemical Society2002Vol. 124(23), pp. 6518–6519
Citations Over TimeTop 10% of 2002 papers
Abstract
The first application of metalloenamines derived from N-sulfinyl imines is reported for the highly diastereoselective addition to aldehydes. Reduction of the beta-hydroxy-N-sulfinyl imine products with catecholborane and LiBHEt3 provides syn- and anti-1,3-amino alcohol derivatives, respectively, with very high diastereomeric ratios.
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