A de Novo Enantioselective Total Synthesis of (−)-Laulimalide
Journal of the American Chemical Society2002Vol. 124(46), pp. 13654–13655
Citations Over TimeTop 10% of 2002 papers
Abstract
An enantioselective total synthesis of the naturally occurring anticancer agent (-)-laulimalide is described. The synthesis is characterized by extensive use of new reaction methodologies based on catalytic asymmetric acyl halide-aldehyde cyclocondensation (AAC) reactions and transformations of the derived enantioenriched beta-lactones. The synthesis also incorporates a unique allenylstannane glycal acetate alkylation and chemoselective ring-closing metathesis reaction.
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