Remarkable Activity of a Novel Cyclic Seleninate Ester as a Glutathione Peroxidase Mimetic and Its Facile in Situ Generation from Allyl 3-Hydroxypropyl Selenide
Journal of the American Chemical Society2002Vol. 124(41), pp. 12104–12105
Citations Over TimeTop 10% of 2002 papers
Abstract
1,2-Oxaselenolane Se-oxide is a novel cyclic seleninate ester that functions as a remarkably efficient glutathione peroxidase mimetic by catalyzing the reduction of tert-butyl hydroperoxide to tert-butyl alcohol in the presence of benzyl thiol. The seleninate ester can be conveniently generated in situ by oxidation of allyl 3-hydroxypropyl selenide with tert-butyl hydroperoxide. Its catalytic activity surpasses that of several other known GPx mimetics containing cyclic selenenamide structures, which were also tested for comparison.
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