G-Quadruplex-Specific Peptide−Hemicyanine Ligands by Partial Combinatorial Selection
Journal of the American Chemical Society2003Vol. 125(19), pp. 5594–5595
Citations Over TimeTop 13% of 2003 papers
Abstract
G-quadruplex DNA-specific ligands were generated using a combinatorial selection of tetrapeptides which were then conjugated to a hemicyanine scaffold. The heterocycle enhanced peptide binding affinity by approximately 1000-fold to give ligands with near micromolar affinity and >40-fold discrimination for quadruplex DNA over duplex.
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