Metal Incorporation in Modified PNA Duplexes
Journal of the American Chemical Society2003Vol. 125(21), pp. 6354–6355
Citations Over TimeTop 16% of 2003 papers
Abstract
Substitution of bipyridine for a nucleobase leads to modified peptide nucleic acid (PNA) single strands that are bridged in the presence of Ni2+ into a duplex containing a combination of hydrogen and coordinative bonds. CD experiments demonstrate that the duplex adopts a structure similar to that of an unmodified 10-bp PNA duplex, and UV melting experiments show a very sensitive dependence of the duplex stability on the substitution of a nucleobase pair with a pair of ligands or a metal-ligand alternative base pair.
Related Papers
- → Formation of Silver(I)-Mediated DNA Duplex and Triplex through an Alternative Base Pair of Pyridine Nucleobases(2002)202 cited
- → Selective and stable base pairing by alkynylated nucleosides featuring a spatially-separated recognition interface(2022)10 cited
- → 1,8-Naphthyridin-2(1H)-ones − Novel Bicyclic and Tricyclic Analogues of Thymine in Peptide Nucleic Acids (PNAs)(2001)48 cited
- → Substituted 1,8-Naphthyridin-2(1H)-ones Are Superior to Thymine in the Recognition of Adenine in Duplex as Well as Triplex Structures(2002)45 cited
- → Nucleobase‐caged peptide nucleic acids: PNA/PNA duplex destabilization and light‐triggered PNA/PNA recognition(2013)9 cited