Synthesis of Spiro Diphosphines and Their Application in Asymmetric Hydrogenation of Ketones

Citations Over TimeTop 10% of 2003 papers

Abstract

Synthesis of chiral diphosphine ligands containing a spiro scaffold was described. The ruthenium complexes of these spiro ligands were found to have extremely high activities (S/C up to 100 000) and enantioselectivities (ee up to 99.5%) in the asymmetric hydrogenation of aromatic, heteroaromatic, and alpha,beta-unsaturated ketones.

Related Papers

• → On the enantioselective hydrogenation of isomeric β-acylamido β-alkylacrylates with chiral Rh(I) complexes—comparison of phosphine ligands and substrates(2002)25 cited
• → New alkylarylamidophosphinephosphinites as chiral diphosphines for asymmetric hydrogenation of activated keto compounds(1993)41 cited
• → Synthesis of novel diphosphines from d-(+)-glucose. Use in asymmetric hydrogenation(2000)19 cited
• → Reduction of Functionalized Alkenes(2008)5 cited
• Synthesis of New Chiral Phosphine Ligands and Their Application in Asymmetric Hydrogenation of Ketones(2004)