Chiral Ru-Based Complexes for Asymmetric Olefin Metathesis: Enhancement of Catalyst Activity through Steric and Electronic Modifications
Citations Over TimeTop 1% of 2003 papers
Abstract
Design, synthesis, characterization, and catalytic activity of six enantiomerically pure Ru-based metathesis catalysts are disclosed (3a-3f). The new chiral catalysts were prepared through steric and electronic alterations of the parent catalyst system (3). The present studies indicate that the effect of structural modifications of chiral complex 3 does not always correspond to those of the related achiral complexes. The present findings illustrate that modified Ru complexes (3e and 3f) deliver reactivity levels that are more than 2 orders of magnitude higher than 3. Reactivity and physical data are provided that shed light on the origin of activity differences. Some members of the new generation of chiral Ru catalysts promote asymmetric ring-opening (AROM) and ring-closing (ARCM) metatheses that cannot be effected by the first generation chiral catalyst (3).
Related Papers
- → An Imine Addition/Ring-Closing Metathesis Approach to the Spirocyclic Core of Halichlorine and Pinnaic Acid(2000)147 cited
- → Total Synthesis of (+)‐Migrastatin(2006)27 cited
- → Metathesis Reactions in Solid‐Phase Organic Synthesis(2010)2 cited
- → ChemInform Abstract: An Imine Addition/Ring‐Closing Metathesis Approach to the Spirocyclic Core of Halichlorine and Pinnaic Acid.(2000)
- → Mastering mono-bond metathesis(2021)