A Stereoselective Synthesis of (−)-Tetrodotoxin
Journal of the American Chemical Society2003Vol. 125(38), pp. 11510–11511
Citations Over TimeTop 1% of 2003 papers
Abstract
An asymmetric synthesis of the fugu fish poison, (-)-tetrodotoxin, is described. The route to this extraordinary target employs a number of unique transformations, foremost of which are two stereospecific C-H bond functionalization reactions. Accordingly, Rh-catalyzed carbene and nitrene C-H insertions facilitate rapid entry to the cyclohexane core of the natural product and make possible the late-stage installation of the tetrasubstituted carbinolamine center.
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