Ageladine A: An Antiangiogenic Matrixmetalloproteinase Inhibitor from the Marine Sponge Agelas nakamurai
Journal of the American Chemical Society2003Vol. 125(51), pp. 15700–15701
Citations Over TimeTop 10% of 2003 papers
Masaki Fujita, Yoichi Nakao, Shigeki Matsunaga, Motoharu Seiki, Yoshifumi Itoh, Jun K. Yamashita, Rob W. M. van Soest, Nobuhiro Fusetani
Abstract
A novel MMP inhibitor, ageladine A (1) with antiangiogenic activity was isolated from a marine sponge Agelas nakamurai. Structure 1 was determined by a combination of spectroscopic and chemical methods to be an unprecedented structure of 4-(4,5-dibromo-1H-pyrrol-2-yl)]-1H-imidazo[4,5-c]pyridin-2-amine.
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