A Practical Catalytic Method for Preparing Highly Substituted Cyclobutanes and Cyclobutenes
Journal of the American Chemical Society2005Vol. 127(11), pp. 3668–3669
Citations Over TimeTop 10% of 2005 papers
Abstract
Tf2NH, an organic acid, efficiently catalyzes (2 + 2) cycloaddition reactions of silyl enol ethers with acrylates or propiolate. The process affords highly substituted cyclobutanes in high yield with high stereoselectivity under practical and environmentally benign conditions. Application for the formation of terpene skeletons and multigram synthesis of four-membered carbocycles were demonstrated.
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