Synthesis and Circular Dichroism of Tetraarylporphyrin−Oligonucleotide Conjugates
Journal of the American Chemical Society2005Vol. 127(12), pp. 4172–4173
Citations Over TimeTop 10% of 2005 papers
Milan Baláž, Andrea E. Holmes, Michele Benedetti, Pamela C. Rodriguez, Nina Berova, Koji Nakanishi, Gloria Proni
Abstract
The preparation and circular dichroic (CD) studies of self-complimentary 8-mer DNA sequences with a porphyrin at the 3' end are presented. Electronic interaction between the two porphyrins (the interchromophoric distance is in the range of 28-40 A), attached to both ends of the double-stranded helix, gives rise to a long-range exciton-coupled CD in the visible region (400-450 nm). The porphyrin chromophores act as sensitive probes of geometrical changes in the DNA backbone and sensitively reflect the double-strand to single-strand transition. This study demonstrates the possibility of using exciton-coupled porphyrin CDs for conformational studies of DNA.
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