Single Turn Peptide Alpha Helices with Exceptional Stability in Water
Journal of the American Chemical Society2005Vol. 127(9), pp. 2974–2983
Citations Over TimeTop 11% of 2005 papers
Abstract
Cyclic pentapeptides are not known to exist in alpha-helical conformations. CD and NMR spectra show that specific 20-membered cyclic pentapeptides, Ac-(cyclo-1,5) [KxxxD]-NH(2) and Ac-(cyclo-2,6)-R[KxxxD]-NH(2), are highly alpha-helical structures in water and independent of concentration, TFE, denaturants, and proteases. These are the smallest alpha-helical peptides in water.
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