Stereoselective Synthesis of Highly Substituted Δ-Pyrrolines: exo-Selective 1,3-Dipolar Cycloaddition Reactions with Azlactones
Journal of the American Chemical Society2004Vol. 126(40), pp. 12776–12777
Citations Over TimeTop 14% of 2004 papers
Abstract
We report herein a silver(I)-catalyzed exo-selective synthesis of highly substituted Delta1-pyrroline scaffolds from amino acid-derived münchnones. Silver acetate successfully catalyzed the cycloaddition reaction of azlactones with alkenes, generating Delta1-pyrrolines in very good yields without isomerization to the Delta2-pyrrolines or decarboxylation.
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