Catalytic Asymmetric Hydroxymethylation of Silicon Enolates Using an Aqueous Solution of Formaldehyde with a Chiral Scandium Complex
Journal of the American Chemical Society2004Vol. 126(39), pp. 12236–12237
Citations Over TimeTop 10% of 2004 papers
Abstract
Catalytic asymmetric hydroxymethylation of silicon enolates has been achieved. In this reaction, an aqueous solution of formaldehyde can be used to realize an easy and safe procedure, and high enantioselectivities have been obtained. This is the first example of catalytic asymmetric reactions in aqueous media with a chiral scandium complex.
Related Papers
- → Chiral Scandium‐Catalyzed Enantioselective Hydroxymethylation of Ketones in Water(2010)72 cited
- → Scandium(III) Fluoride as a Novel Catalyst for Hydroxymethylation of Dimethylsilyl Enolates in Aqueous Media(2008)9 cited
- → ChemInform Abstract: Scandium(III) Fluoride as a Novel Catalyst for Hydroxymethylation of Dimethylsilyl Enolates in Aqueous Media.(2008)1 cited
- → ChemInform Abstract: Synthesis of N‐(Amidomethyl)‐ and N‐(Imidomethyl)‐α‐amino Acid Esters by Reaction of α‐Amino Acid Esters with Formaldehyde and Amides or Imides(1997)
- Properties of Cupric Salt Catalysts of 12-heteropoly Acids and Catalytic Activity for the Oxidation of Methanol(1986)