Highly Efficient Synthesis of β-Amino Acid Derivatives via Asymmetric Hydrogenation of Unprotected Enamines
Journal of the American Chemical Society2004Vol. 126(32), pp. 9918–9919
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Yi Hsiao, Nelo R. Rivera, Thorsten Rosner, Shane W. Krska, Eugenia Njolito, Fang Wang, Yongkui Sun, Joseph D. Armstrong, Edward J. J. Grabowski, Richard D. Tillyer, Felix Spindler, Christophe Malan
Abstract
A direct asymmetric hydrogenation of unprotected enamino esters and amides is described. Catalyzed by Rh complexes with Josiphos-type chiral ligands, this method gives beta-amino esters and amides in high yield and high ee (93-97% ee). No acyl protection/deprotection is required.
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