Conductance Titration of Single-Peptide Molecules
Journal of the American Chemical Society2004Vol. 126(17), pp. 5370–5371
Citations Over TimeTop 10% of 2004 papers
Abstract
We have measured the conductance of single peptides covalently bonded to two Au electrodes via S-Au bonds by repeatedly forming a large number of molecular junctions. The conductance decreases exponentially with the peptide length, with a decay constant of beta = 0.9 +/- 0.1 A-1, suggesting that tunneling is the mechanism of electron transport in the peptides. The conductance of the peptides is sensitive to the solution pH, due to the protonation/deprotonation of the amine and carboxyl groups of the peptides, which provides titration measurements based on single-molecule conductance.
Related Papers
- → Remarkable fluorescence change based on the protonation–deprotonation control in organic crystals(2013)126 cited
- → The synthesis and photophysical studies of cyclometalated Pt(ii) complexes with C,N,N-ligands containing imidazolyl donors(2011)18 cited
- → Molecular Orbital Calculations of Diketo‐dipyridyl‐pyrrolopyrrole, Diketo and Dithioketo‐diphenyl‐pyrrolopyrrole on Protonation and Deprotonation(1993)8 cited
- → Solution and Solid State Properties of 1,4‐Diketo‐3,6‐bis‐(4'‐pyridyl)‐pyrrolo‐[3,4‐c]‐pyrrole on Protonation and Deprotonation(1993)26 cited
- → The Optimum pH of Oxidoreductases: A Comparison Between Experimental and Calculated pH Optimum(2002)2 cited