A Limiting Speed for Protein Folding at Low Solvent Viscosity
Journal of the American Chemical Society2004Vol. 126(11), pp. 3398–3399
Citations Over TimeTop 15% of 2004 papers
Abstract
Because protein folding dynamics are heavily overdamped, Kramers theory predicts the rate of folding to scale inversely with the reaction friction, which is usually interpreted to mean the solvent viscosity. This does not mean, however, that the speed of folding can increase without limit as solvent viscosity decreases. We show that, in a sufficiently fast-folding protein, the folding speed approaches a finite limit at low solvent viscosity, indicating a reaction controlled by internal friction.
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