(P)-Helicene Displays Chiral Selection in Binding to Z-DNA
Journal of the American Chemical Society2004Vol. 126(21), pp. 6566–6567
Citations Over TimeTop 10% of 2004 papers
Abstract
Enantiomeric helicenes of (P)-A and (M)-A were synthesized. The binding of the helicenes to B- and Z-DNA was studied quantitatively by CD, equilibrium dialysis, and fluorescence spectroscopy. Enantiomeric (P)-A not only bound selectively to Z-DNA but also effectively converted the B-DNA conformation to Z-DNA. The enantioselectivity of the helicenes offers a new route for the rational design of inhibitors of biological functions that may depend on Z-DNA.
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