Total Synthesis of Cribrostatin IV: Fine-Tuning the Character of an Amide Bond by Remote Control
Journal of the American Chemical Society2005Vol. 127(13), pp. 4596–4598
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Collin Chan, Richard Heid, Shengping Zheng, Jinsong Guo, Bishan Zhou, Takeshi Furuuchi, Samuel J. Danishefsky
Abstract
We report the enantioselective total synthesis of cribrostatin IV (1). Key features of this synthesis involve the convergent coupling of two highly functionalized homochiral components followed by a "lynchpin" Mannich cyclization to establish the pentacyclic core (cf. 19 --> 20).
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