Monitoring Dopamine Release from Single Living Vesicles with Nanoelectrodes
Journal of the American Chemical Society2005Vol. 127(25), pp. 8914–8915
Citations Over TimeTop 12% of 2005 papers
Wu Wen, Wei‐Hua Huang, Wei Wang, Zongli Wang, Jie-Ke Cheng, Tao Xu, Rongying Zhang, Yu Chen, Jie Liu
Abstract
Carbon fiber nanoelectrodes (tip diameter = ca. 100 nm) have been first used to monitor real-time dopamine release from single living vesicles of single rat pheochromocytoma (PC12) cells. The experiments show that active and inactive release sites exist on the surface of cells, and the spatial distributions have been differentiated even in the same active release zone. It is first demonstrated that multiple vesicles can sequentially release dopamine at the same site of the cell surface, which possibly plays the main role in the dopamine release from PC12 cells.
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