Dendrimer-like PEO Glycopolymers Exhibit Anti-Inflammatory Properties
Journal of the American Chemical Society2005Vol. 127(29), pp. 10132–10133
Citations Over TimeTop 10% of 2005 papers
Shyam M. Rele, Wanxing Cui, Lianchu Wang, Sijian Hou, Ginger Barr-Zarse, Daniel Taton, Yves Gnanou, Jeffrey D. Esko, Elliot L. Chaikof
Abstract
A new class of high molecular weight polysulfated PEO dendrimer-like glycopolymer has been synthesized by a combination of arm-first and core-first methodologies followed by trichloroacetimidate glycosidation as a facile bioconjugation strategy. An L-selectin antagonist was identified that exhibits 103-fold greater activity than other multivalent sLex glycopolymers and 20-50 times greater potency than other linear heparinoids. A significant reduction in inflammatory cell recruitment was observed in vivo.
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