Oxidative C−H Activation/C−C Bond Forming Reactions: Synthetic Scope and Mechanistic Insights
Journal of the American Chemical Society2005Vol. 127(20), pp. 7330–7331
Citations Over TimeTop 1% of 2005 papers
Abstract
This paper describes a new palladium-catalyzed method for C-H activation/carbon-carbon bond formation with hypervalent iodine arylating agents. This transformation has been applied to a variety of arene and benzylic substrates containing different directing groups (pyridines, quinolines, oxazolidinones, and amides) and proceeds with high levels of regiocontrol. Mechanistic experiments provide preliminary evidence in support of an unusual mechanism for this transformation involving a Pd(II)/Pd(IV) catalytic cycle.
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