Locked Nucleic Acid Molecular Beacons
Journal of the American Chemical Society2005Vol. 127(45), pp. 15664–15665
Citations Over TimeTop 10% of 2005 papers
Abstract
A novel LNA-MB (molecular beacon based on locked nucleic acid bases) has been designed and investigated. It exhibits very high melting temperature and is thermally stable, shows superior single base mismatch discrimination capability, and is stable against digestion by nuclease and has no binding with single-stranded DNA binding proteins. The LNA-MB will be widely useful in a variety of areas, especially for in vivo hybridization studies.
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