Room Temperature Hydroalkylation of Electron-Deficient Olefins: sp3 C−H Functionalization via a Lewis Acid-Catalyzed Intramolecular Redox Event
Journal of the American Chemical Society2005Vol. 127(35), pp. 12180–12181
Citations Over TimeTop 10% of 2005 papers
Abstract
A practical method for the intramolecular hydroalkylation of electron-deficient olefins has been developed. The direct transformation of benzylic, tertiary, and sterically hindered secondary sp3 C-H bonds into C-C bonds under the action of a catalytic amount of a variety of Lewis acids is described. The mechanism of these transformations is proposed to involve a tandem hydride transfer/cyclization sequence.
Related Papers
- → Intramolecular Hydrogen Bond Interaction in Selected Diols(2003)17 cited
- → Intramolecular isotope effects in the reactions of CF32+ and CO22+ with HD(2001)28 cited
- → Nature of weak inter-and intramolecular interactions in crystals 8. Influence of intermolecular contacts on the strength of intramolecular O-H...N bonds in crystals of 3-(2-hydroxyphenyl)-1,2,4-triazoles(2006)3 cited
- → Stimulation intramolecular F⋯H hydrogen bond by intramolecular N → Si interaction in Si-fluoro derivatives of 8-mercaptoquinoline: DFT and MP2 calculations(2018)1 cited
- Conformations and Intramolecular Hydrogen Bonds of a Series of Amino-alcohols(2013)