Mitochondrial Targeting of Selective Electron Scavengers: Synthesis and Biological Analysis of Hemigramicidin−TEMPO Conjugates
Journal of the American Chemical Society2005Vol. 127(36), pp. 12460–12461
Citations Over TimeTop 10% of 2005 papers
Peter Wipf, Jingbo Xiao, Jianfei Jiang, Natalia A. Belikova, Vladimir A. Tyurin, Mitchell P. Fink, Valerian E. Kagan
Abstract
Synthetic hemigramicidin S-peptidyl TEMPO conjugates are effectively delivered into cells and mitochondria, where they act as electron scavengers and exert protection against apoptosis. Our delivery approach is based on the use of specific structural signaling features recognizable by cells as mitochondria targeting sequences and offers considerable therapeutic anti-apoptotic potential.
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