Strong Resistance of Phosphorylcholine Self-Assembled Monolayers to Protein Adsorption: Insights into Nonfouling Properties of Zwitterionic Materials

Citations Over TimeTop 1% of 2005 papers

Abstract

In this work, we show the strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMs) to protein adsorption and examine key factors leading to their nonfouling behavior using both experimental and molecular simulation techniques. Zwitterions with a balanced charge and minimized dipole are excellent candidates as nonfouling materials due to their strong hydration capacity via electrostatic interactions.

Related Papers

• → Electrostatics in Protein Binding and Function(2002)150 cited
• → Biocompatible and biodegradable phosphorylcholine ionomers with reduced protein adsorption and cell adhesion(2006)22 cited
• → Cytocompatible biointerface on poly(lactic acid) by enrichment with phosphorylcholine groups for cell engineering(2006)25 cited
• → Polymeric biomaterials: influence of phosphorylcholine polar groups on protein adsorption and complement activation(1994)57 cited
• → Resisting Protein but Promoting Cell Adhesion by Choline Phosphate: A Comparative Study with Phosphorylcholine(2018)5 cited