Total Synthesis of Reblastatin
Journal of the American Chemical Society2005Vol. 127(43), pp. 15026–15027
Citations Over TimeTop 10% of 2005 papers
Abstract
Enantioselective total synthesis of reblastatin is described. The synthesis highlights hydrozirconation, transmetalation, aldehyde addition sequence to install E-trisubstituted olefin and C7 stereocenter, and the first use of an intramolecular Buchwald-like amidation reaction to close the 19-membered macrolactam.
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