Total Synthesis of Lucilactaene, A Cell Cycle Inhibitor Active in p53-Inactive Cells
Journal of the American Chemical Society2005Vol. 127(46), pp. 16038–16039
Citations Over TimeTop 20% of 2005 papers
Abstract
Hetero-bis-metalated 1,3-butadiene is employed in the lynchpin coupling of synthetic fragments of the side chain of the antitumor agent, lucilactaene. Sequential Stille and Suzuki-Miyaura couplings interpolate this unique boron/tin diene into the pentaene chain. The total synthesis of lucilactaene was accomplished efficiently, in just eight linear steps.
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