A Solution to the 2-Pyridyl Organometallic Cross-Coupling Problem: Regioselective Catalytic Direct Arylation of Pyridine N-Oxides
Journal of the American Chemical Society2005Vol. 127(51), pp. 18020–18021
Citations Over TimeTop 1% of 2005 papers
Abstract
Direct arylation reactions of pyridine N-oxides occur in excellent yield with complete selectivity for the 2-position with a wide range of aryl bromides. This reactivity permits the use of inexpensive, commercially available, and bench-stable pyridine N-oxides as replacements for problematic 2-metallapyridines in palladium-catalyzed cross-coupling reactions.
Related Papers
- → Recent Advances in the Regioselective Synthesis of Pyrazoles(2011)73 cited
- → Perfectly Regioselective and Sequential Protection of Glucopyranosides(2010)53 cited
- → Heterolytic CH-bond activation in the synthesis of Ni{(2-aryl-κC2)pyridine-κN}2 and derivatives(2007)20 cited
- → Photoinduced regioselective arylation of N-vinyllactams and methylthiazoles by tetrachlorophthalimides(2013)1 cited
- → β-Aminoenones in the regioselective synthesis of 1,3,5-trialkylpyrazoles. The influence of the substituents in the mechanism and the regioselectivity of the reaction(1998)12 cited