Preparation and Evaluation of Unimolecular Pentavalent and Hexavalent Antigenic Constructs Targeting Prostate and Breast Cancer: A Synthetic Route to Anticancer Vaccine Candidates
Journal of the American Chemical Society2006Vol. 128(8), pp. 2715–2725
Citations Over TimeTop 10% of 2006 papers
Govind Ragupathi, Fusataka Koide, Philip O. Livingston, Young Shin Cho, Atsushi Endo, Qian Wan, Maria Spassova, Stacy J. Keding, Jennifer R. Allen, Ouathek Ouerfelli, Rebecca M. Wilson, Samuel J. Danishefsky
Abstract
Several novel, fully synthetic, carbohydrate-based antitumor vaccines have been assembled. Each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Recent advances in synthetic methodology have allowed for the incorporation of a complex oligosaccharide terminating in a sialic acid residue (i.e., GM2) as one of the carbohydrate antigens. Details of the vaccine synthesis as well as the results of preliminary immunological investigations are described herein.
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