Cell-Permeable and Biocompatible Polymeric Nanoparticles for Apoptosis Imaging
Journal of the American Chemical Society2006Vol. 128(11), pp. 3490–3491
Citations Over TimeTop 10% of 2006 papers
Kwangmeyung Kim, Misu Lee, Hyungkyu Park, Jong‐Ho Kim, Sung‐Won Kim, Hesson Chung, Kuiwon Choi, In-San Kim, Baik Lin Seong, Ick Chan Kwon
Abstract
Here, we report for the first time cell-permeable and biocompatible polymeric nanoparticles consisting of a polymer conjugated to a near-infrared (NIR) fluorescence (Cy5.5)-linked effector caspase-specific peptide. The close spatial proximity of the NIR fluorochromes in polymeric nanoparticles results in an autoquenched state, but polymer nanoparticles give rise to strong NIR fluorescence signal under apoptotic cells. Thus, the smart polymeric nanoparticle developed here is an attractive probe for real-time imaging of apoptosis in single cells.
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