Total Synthesis of Dolabelide D
Journal of the American Chemical Society2006Vol. 128(9), pp. 2796–2797
Citations Over TimeTop 10% of 2006 papers
Abstract
The first total synthesis of dolabelide D (or of any of the closely related dolabelides) has been achieved with a longest linear sequence of 17 steps. Key features of the synthesis include an application of the catalytic asymmetric silane alcoholysis, the tandem silylformylation-crotylsilylation, and a Brook-like 1,4-carbon to oxygen silyl migration.
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