Nanopore Formation and Phosphatidylserine Externalization in a Phospholipid Bilayer at High Transmembrane Potential
Journal of the American Chemical Society2006Vol. 128(19), pp. 6288–6289
Citations Over TimeTop 1% of 2006 papers
P. Thomas Vernier, Matthew J. Ziegler, Yinghua Sun, W. V. Chang, Martin A. Gundersen, D. Peter Tieleman
Abstract
Atomic-resolution molecular dynamics simulations of lipid bilayers containing 7% phosphatidylserine (PS) on one leaflet are consistent with experimental observations of membrane poration and PS externalization in living cells exposed to nanosecond, megavolt-per-meter electric pulses. Nanometer-diameter aqueous pores develop within nanoseconds after application of an electric field of 450 mV/nm, and electrophoretic transport of the anionic PS headgroup along the newly constructed hydrophilic pore surface commences even while pore formation is still in progress.
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