Water Soluble Cryptophanes Showing Unprecedented Affinity for Xenon: Candidates as NMR-Based Biosensors
Citations Over TimeTop 10% of 2006 papers
Abstract
Cryptophanes bearing OCH(2)COOH groups in place of the methoxy groups represent a new class of xenon-carrier molecules soluble in water at biological pH. By using (1)H and (129)Xe NMR (thermally- and laser-polarized dissolved gas), the structural and dynamical behaviors of these host molecules as well as their interaction with xenon are studied. They are shown to exist in aqueous solution under different conformations in very slow exchange. A saddle form present for one of these conformations could explain the (1)H NMR spectra. Whereas the cryptophanes in such a conformation are unable to complex xenon, unprecedented high binding constants are found for cryptophanes in the other canonical crown-crown conformation. These host molecules could therefore be valuable candidates for biosensing using (129)Xe MRI.
Related Papers
- → Separation of Xenon from Noble Gas Mixtures of Argon, Krypton, and Xenon Using Gas Hydrate Technology(2023)11 cited
- → One-dimensional fluid simulations of a helium - xenon filled ac colour plasma flat panel display pixel(1997)32 cited
- → Time behaviour of the scintillation light in mixtures of liquid argon and xenon(1996)11 cited
- → The performance of the GPSC/MSGC hybrid detector with neon-xenon gas mixtures(2004)3 cited
- → The performance of the GPSC/MSGC hybrid detector with neon-xenon gas mixtures(2003)