A Direct, One Step Synthesis of Imidazoles from Imines and Acid Chlorides: A Palladium Catalyzed Multicomponent Coupling Approach
Journal of the American Chemical Society2006Vol. 128(18), pp. 6050–6051
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Abstract
A palladium-catalyzed one-step synthesis of imidazoles from imines and acid chlorides is described. A plausible mechanism for this multicomponent reaction is provided, which explains the selective incorporation of two different imines into the final product with perfect regiocontrol. Overall, this catalytic process provides a modular method to prepare imidazoles directly from building blocks that are all either commercially available or readily generated.
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