Synthesis of Homoallylic Amines via the Palladium-Catalyzed Decarboxylative Coupling of Amino Acid Derivatives
Journal of the American Chemical Society2006Vol. 128(31), pp. 10002–10003
Citations Over TimeTop 10% of 2006 papers
Abstract
Protected homoallylic amines are synthesized by the decarboxylative coupling of alpha-amino acid derivatives. The catalytic C-C bond-forming reaction relies on the bioinspired decarboxylative metalation of alpha-amino acids to produce alpha-amino anion equivalents. The alpha-amino anion equivalents are intercepted by pi-allyl palladium electrophiles to produce substituted homoallylic amines.
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