Modified Pyrimidines Specifically Bind the Purine Riboswitch
Journal of the American Chemical Society2006Vol. 128(44), pp. 14214–14215
Citations Over TimeTop 10% of 2006 papers
Abstract
The purine riboswitch is a genetic regulatory element found in the 5'-untranslated regions of Gram-positive bacteria that regulates expression of the mRNA specifically in response to either guanine or adenine. We report that the adenine-responsive RNA element is also capable of specifically recognizing pyrimidine compounds bearing modifications at the 6- or 5,6-positions in a fashion similar to that of purine compounds. Using isothermal titration calorimetry and X-ray crystallography, the binding of these compounds is characterized.
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