Optical Imaging of Bacterial Infection in Living Mice Using a Fluorescent Near-Infrared Molecular Probe
Journal of the American Chemical Society2006Vol. 128(51), pp. 16476–16477
Citations Over TimeTop 10% of 2006 papers
W. Matthew Leevy, Seth T. Gammon, Hua Jiang, James R. Johnson, Dustin J. Maxwell, Erin Jackson, Manuel Márquez, David Piwnica‐Worms, Bradley D. Smith
Abstract
An optical imaging probe was synthesized by attaching a near-infrared carbocyanine fluorophore to an affinity group containing two zinc(II) dipicolylamine (Zn-DPA) units. The probe has a strong and selective affinity for the surfaces of bacteria, and it was used to image infections of Gram-positive S. aureus and Gram-negative E. coli bacteria in living nude mice. After intravenous injection, the probe selectively accumulates at the sites of localized bacterial infections in the thigh muscles of the mice.
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