Azidoproline Containing Helices: Stabilization of the Polyproline II Structure by a Functionalizable Group
Journal of the American Chemical Society2006Vol. 129(3), pp. 466–467
Citations Over TimeTop 10% of 2006 papers
Abstract
The conformation and functionalizability of 4-azidoproline containing polyprolines was studied. The conformational analyses demonstrate that the PPII helix is stabilized by (4R)Azp and destabilized by (4S)Azp. Functionalization of Azp containing polyprolines was accomplished efficiently in a differential fashion by “click chemistry”, rendering Azp containing polyprolines attractive molecular scaffolds.
Related Papers
- → Left-handed Polyproline II Helices Commonly Occur in Globular Proteins(1993)467 cited
- → Highly active higher coordinated copper(i)–N-heterocyclic chalcogenone catalysed click chemistry(2023)9 cited
- → Synthesis of artemisinin derived glycoconjugates inspired by click chemistry(2019)14 cited
- → Synthesis and conformational analysis of macrocyclic peptides consisting of both α‐helix and polyproline helix segments(2013)5 cited
- Structural and Conformational Analysis of Macrocyuclic α-Helix and Polyproline Helix Coexisting Peptides(2014)