Highly Enantioselective Friedel−Crafts Reaction of Indoles with Imines by a Chiral Phosphoric Acid
Journal of the American Chemical Society2007Vol. 129(6), pp. 1484–1485
Citations Over TimeTop 1% of 2007 papers
Abstract
Highly enantioselective Friedel−Crafts reactions of indoles with imines catalyzed by a chiral phosphoric acid are developed, affording the 3-indolyl methanamine derivatives with up to >99% ee for a wide range of substrates.
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