Enantioselective Pd-Catalyzed Allylation Reaction of Fluorinated Silyl Enol Ethers
Journal of the American Chemical Society2007Vol. 129(5), pp. 1034–1035
Citations Over TimeTop 10% of 2007 papers
Abstract
An enantioselective Pd-catalyzed allylation reaction of fluorinated silyl enol ethers is reported. This reaction provides a stereoselective and efficient approach to allylated tertiary α-fluoroketones from achiral fluorinated precursors. A variety of cyclic silyl enol ether can be used, and the yields of the desired products range from 52 to 93%, and the enantiomeric excesses range from 83 to 95% ee.
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