Copper(II)-Catalyzed Aminohydroxylation of Olefins
Journal of the American Chemical Society2007Vol. 129(7), pp. 1866–1867
Citations Over TimeTop 10% of 2007 papers
Abstract
We report a novel copper(II)-catalyzed aminohydroxylation in which both heteroatoms of an N-sulfonyl oxaziridine are added across an alkene in a regioselective fashion. A variety of styrenes and electron-rich alkenes can be aminohydroxylated using this protocol. Preliminary investigations indicate that this new process is a rare non-oxenoid reaction of N-sulfonyl oxaziridines, involving a stepwise, polar mechanism rather than a concerted process.
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