Organocatalysis in Radical Chemistry. Enantioselective α-Oxyamination of Aldehydes
Journal of the American Chemical Society2007Vol. 129(14), pp. 4124–4125
Citations Over TimeTop 1% of 2007 papers
Abstract
We have developed an efficient radical α-oxyamination reaction using chiral organocatalysts. The reaction can be carried out with inexpensive SET reagents, and a reasonably broad substrate scope has been established. Good to high enantioselectivity for the α-oxygenated products are obtained using 20 mol % of the catalyst. The methodology reported in this work adds to the repertoire of asymmetric radical reactions that can be conducted using organocatalysts.
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