A Red Cy3-Based Biarsenical Fluorescent Probe Targeted to a Complementary Binding Peptide
Journal of the American Chemical Society2007Vol. 129(28), pp. 8672–8673
Citations Over TimeTop 10% of 2007 papers
Abstract
We have synthesized a red biarsenical fluorescent probe, AsCy3, with good photostability, low pH sensitivity, high absorbance, and good quantum yield. It is directed specifically to a small tetracysteine peptide binding motif, Cy3TAG (CysCysLysAlaGluAlaAlaCysCys), in the presence of other tetracysteine tags. This new probe provides a FRET partner to biarsenical dye FlAsH, making this discovery an important step toward a whole toolkit of colored probes directed to different small peptide motifs.
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