Singlet Oxygen Production by Peptide-Coated Quantum Dot−Photosensitizer Conjugates
Citations Over TimeTop 10% of 2007 papers
Abstract
Peptide-coated quantum dot-photosensitizer conjugates were developed using novel covalent conjugation strategies on peptides which overcoat quantum dots (QDs). Rose bengal and chlorin e6, photosensitizers (PSs) that generate singlet oxygen in high yield, were covalently attached to phytochelatin-related peptides. The photosensitizer-peptide conjugates were subsequently used to overcoat green- and red-emitting CdSe/CdS/ZnS nanocrystals. Generation of singlet oxygen could be achieved via indirect excitation through Förster (fluorescence) resonance energy transfer (FRET) from the nanocrystals to PSs, or by direct excitation of the PSs. In the latter case, by using two color excitations, the conjugate could be simultaneously used for fluorescence imaging and singlet oxygen generation. Singlet oxygen quantum yields as high as 0.31 were achieved using 532-nm excitation wavelengths.
Related Papers
- → Singlet Oxygen in Antimicrobial Photodynamic Therapy: Photosensitizer-Dependent Production and Decay in E. coli(2013)76 cited
- → Phosphazene-bound Rose Bengal: A novel photosensitizer for singlet oxygen generation(1991)25 cited
- → Sono-activatable Photosensitizer for Photodynamic Therapy(2014)4 cited
- → Evaluation of singlet oxygen luminescence of a novel chlorin photosensitizer(2018)2 cited
- Numerical simulation of singlet oxygen generation by a porphyrin-based photosensitizer(2008)