Highly Regio-, Diastereo-, and Enantioselective Pd-Catalyzed Allylic Alkylation of Acyclic Ketone Enolates with Monosubstituted Allyl Substrates
Journal of the American Chemical Society2007Vol. 129(25), pp. 7718–7719
Citations Over TimeTop 10% of 2007 papers
Abstract
Pd-catalyzed asymmetric allylic alkylation reactions of acyclic ketones with monosubstituted allyl substrates using 1,1‘-P,N-ferrocene with H as substituent on the oxazoline ring as ligand gave products having two chiral centers with high yields and with high regio-, diastereo-, and enantioselectivities, with the ratio of branched and linear products being 98:2, anti:syn ratio for branched products being 7−21:1, and ee for the anti-products being 92−99%.
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