Organocatalysis in Conjugate Amine Additions. Synthesis of β-Amino Acid Derivatives
Journal of the American Chemical Society2007Vol. 129(26), pp. 8064–8065
Citations Over TimeTop 10% of 2007 papers
Abstract
Conjugate addition of O-protected hydroxylamines to pyrazole-derived enoates proceeds with high efficiency and enantioselectivity when chiral thioureas are used as activators. A wide variety of substrates undergo conjugate amine addition providing access to enantioenriched β-amino acid derivatives. Structural requirements for the optimal thiourea catalyst have been established, and the results suggest that it operates as a bifunctional catalyst.
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