Array-Based Sensing of Proteins Using Conjugated Polymers
Journal of the American Chemical Society2007Vol. 129(32), pp. 9856–9857
Citations Over TimeTop 1% of 2007 papers
Oscar R. Miranda, Chang‐Cheng You, Ronnie L. Phillips, Ik‐Bum Kim, P. S. Ghosh, Uwe H. F. Bunz, Vincent M. Rotello
Abstract
A sensor array comprising six functionalized poly(p-phenyleneethynylene) polymers was constructed and used to detect and identify protein analytes. The presence of proteins alters the fluorescence properties of the polymers, generating a distinct fluorescence response pattern for a given protein. Linear discriminant analyses accurately differentiate the patterns of 17 proteins at nano- to micromolar concentrations. An identification accuracy of 97% was obtained on the basis of the tests with 68 unknown protein samples from the training set.
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