Iron-Catalyzed Highly Regio- and Stereoselective Conjugate Addition of 2,3-Allenoates with Grignard Reagents
Journal of the American Chemical Society2007Vol. 129(47), pp. 14546–14547
Citations Over TimeTop 10% of 2007 papers
Abstract
An efficient highly regio- and stereoselective iron-catalyzed conjugate addition of 2,3-allenoates with primary or secondary alkyl, phenyl, or vinyl Grignard reagents to synthesize multi-substituted beta,gamma-unsaturated enoates has been reported. The in situ formed magnesium dienolate may readily react with different electrophilic reagents to construct an allylic quaternary carbon at the alpha-position of the ester group.
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